MAp44, a Human Protein Associated with Pattern Recognition Molecules of the Complement System and Regulating the Lectin Pathway of Complement Activation

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Deciphering complement receptor type 1 interactions with recognition proteins of the lectin complement pathway.

Complement receptor type 1 (CR1) is a membrane receptor expressed on a wide range of cells. It is involved in immune complex clearance, phagocytosis, and complement regulation. Its ectodomain is composed of 30 complement control protein (CCP) modules, organized into four long homologous repeats (A-D). In addition to its main ligands C3b and C4b, CR1 was reported to interact with C1q and mannan-...

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ژورنال

عنوان ژورنال: The Journal of Immunology

سال: 2009

ISSN: 0022-1767,1550-6606

DOI: 10.4049/jimmunol.0902388